陈影助理教授，1992年生，博士生导师，课题组长。陈影课题组成立于2024年3月1日，现有12名成员，包括中国医学科学院北京协和医学院准长聘助理教授1名，助理研究员1名，博士后2名，研究生7名，本科生1名。团队领导人陈影助理教授，师从化学蛋白质组学专家王初教授和药物化学家Jack Taunton教授，长期从事新型药物靶点挖掘、小分子抑制剂开发、疾病分子机制解析等工作。迄今以第一作者在Nature Chemistry等国际著名杂志上发表论文12篇，1篇论文被Molecular Cell专文评述，获批授权专利1项。主持国家自然科学基金青年科学基金、北京市高层次创新创业人才支持计划科技新星项目、北京市自然科学基金面上项目、中国医学科学院创新工程-医学健康领军科技人才养募专项、中国医学科学院北京协和医学院科技人才支持专项协和新星项目、清华大学《膜生物学全国重点实验室》开放课题，以骨干身份参与新药创制重大专项。担任PharmaceuticalScience Advances青年编委，并获优秀青年编委。
发表论文如下：
21.Boyi Chen, Hongyang Guo,Zhijian Yan, Wenjie Lu, Chun Li, Shimin Xu, Yanling Zhang, Haodong Guo,Shaopeng Sun, Xuege Sun, Shangxun Zhao, Qiaoling Shangguan, Yidong Chen, LeiLu, Zhaofa Wu, Ying Chen*, Wei Qin*. In vivo-compatible spatialmulti-omics via hydrogen peroxide-independent APEX2 labeling. bioRxiv 2026.03.13.711744;
20. Combs JB, Peacock DM,Craven GB, Jung S, Chen Y, Le SM, Taunton J, Shokat KM.Benzoxaboroles are structurally unique binders of eukaryotic translationinitiation factor 4E. J. Am. Chem. Soc. 2026.
19. Xu, F., Huang, H., Peng,K., Jian, C., Wu, H., Jing, Z., Qiu, S., Chen, Y., Liu, K., Fu, L.,Wang, Y., Yang, J., Duan, X., Wang, C., Cheng, H., & Wang, X. ROMO1overexpression protects the mitochondrial cysteinome from oxidations in aging. Nat.Commun. 16, 5133 (2025).
18. Wang, Q., Liu, Z., Wang, Y.,Liu, Y., Chen, Y., Zhang, S., Zeng, W., Li, D., Yang, F., He, Z.,Xiao, W., Liu, C., & Wang, C. Quantitative chemoproteomics revealsdopamine’s protective modification of Tau. Nat. Chem. Biol. 21,1341–1350 (2025).
17. Craven, G. B.; Chu, H.;Sun, J. D.; Carelli, J. D.; Coyne, B.; Chen, H.; Chen, Y.; Ma, X.;Das, S.; Kong, W.; Zajdlik, A. D.; Yang, K. S.; Reisberg, S. H.; Thompson, P.A.; Lipford, J. R.; Taunton, J. Mutant-selective AKT inhibition through lysinetargeting and neo-zinc chelation. Nature 637, 205–214(2025).
16. Sun, X.#; Chen,Y.#; Yang, C.; Yang, S.; Lin, W.; Quan, B.; Pan, X.; Ding, Q.; Chen,X.; Wang, C.; Qin, W., Chemical recording of pump-specific drugefflux in living cells. Angew. Chem. In.t Ed. Engl. 2024Sep 26:e202409282.
15. Chen, Y.; Craven,GB; Kamber RA; Cuesta, A.; Zhersh, S.; Moroz YS; Bassik MC; Taunton, J. Directmapping of ligandable tyrosines and lysines in cells with chiral sulfonylfluoride probes. Nat. Chem. 2023.15(11),1616-1625.
14. Chen, Y.;Liu, Y.; Lan, T.; Qin, W.; Zhu, Y.; Qin, K.; Gao, J.; Wang, H.; Hou, X.; Chen,N.; Friedmann Angeli, J. P.; Conrad, M.; Wang, C., Quantitative Profilingof Protein Carbonylations in Ferroptosis by an Aniline-Derived Probe. J.Am. Chem. Soc. 2018,140(13), 4712-4720.
13. Li, X.#; Xiong,X.#; Zhang, M.#; Wang, K.#; Chen, Y.#; Zhou, J.; Mao, Y.; Lv, J.;Yi, D.; Chen, X. W.;Wang, C. ; Qian, S. B.; Yi, C., Base-ResolutionMapping Reveals Distinct m1A Methylome in Nuclear- and Mitochondrial-EncodedTranscripts. Mol. Cell 2017, 68 (5),993–1005. (# Equal Contribution)
12. Chen, Y.;Cong, Y.; Quan, B.; Lan, T.; Chu, X.; Ye, Z.; Hou, X.; Wang, C.,Chemoproteomic profiling of targets of lipid-derived electrophiles bybioorthogonal aminooxy probe. Redox Biol. 2017, 12,712-718.
11. Chen, Y. #;Quan, B. #; Li, Y. #; Liu Y.; Qin, W.; Wang, C., Quantitative profiling of PTMstiochiometry by resolvable mass tags. RSC Chem. Biol. 2022, 3 (11),1320-1324. (# Equal Contribution)
10. Chen, Y.;Qin, W.; Li, Z.; Guo, Z.; Liu, Y.; Lan, T.; Wang, C., Site-specificchemoproteomic profiling of targets of glyoxal. Future Med. Chem. 2019, 11 (23),2979-2987.
9. Chen, Y.;Liu, Y.; Hou, X.; Ye, Z.; Wang, C., Quantitative and Site-SpecificChemoproteomic Profiling of Targets of Acrolein. Chem. Res. Toxicol. 2019, 32 (3),467-473.
8. Chen, Y. #;Qin, W. #; Wang, C., Functional proteomics driven by chemical and computationalapproaches. Chin. J. Chem. 2022, 40, 628-634. (# EqualContribution)
7. Chen, Y.;Wang, C., Profiling of Protein Carbonylations in Ferroptosis by ChemicalProteomics. Methods Mol. Biol. 2022, 2543,141-153.
6. Chen, Y.; Qin,W.; Wang, C., Chemoproteomic profiling of protein modifications bylipid-derived electrophiles. Curr. Opin. Chem. Biol. 2016,30, 37-45.
5. Chen, C. #; Chen, Y. #;Lu, J. #; Chen, Z.; Wang, C.; Pi, R., Acrolein-conjugated proteomics in brainsof adult C57BL/6 mice chronically exposed to acrolein and aged APP/PS1transgenic AD mice. Toxicol. Lett. 2021, 344,11–17. (# Equal Contribution)
4. Dubiella, C.; Pinch, B. J.;Koikawa, K.; Zaidman, D.; Poon, E.; Manz, T. D.; Nabet, B.; He, S.; Resnick,E.; Rogel, A.; Langer, E. M.; Daniel, C. J.; Seo, H. S.; Chen, Y.;Adelmant, G.; Sharifzadeh, S.; Ficarro, S. B.; Jamin, Y.; Martins da Costa, B.;Zimmerman, M. W.; Lian, X.; Kibe, S.; Kozono, S.; Doctor, Z. M.; Browne, C. M.;Yang, A.; Stoler-Barak, L.; Shah, R. B.; Vangos, N. E.; Geffken, E. A.; Oren,R.; Koide, E.; Sidi, S.; Shulman, Z.; Wang, C.; Marto, J. A.; Dhe-Paganon, S.;Look, T.; Zhou, X. Z.; Lu, K. P.; Sears, R. C.; Chesler, L.; Gray, N. S.;London, N., Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driventumors in vivo. Nat. Chem. Biol. 2021, 17 (9),954-963.
3. Qin, W.; Zhang, Y.; Tang, H.;Liu, D.; Chen, Y.; Liu, Y.; Wang, C., Chemoproteomic profiling ofitaconation by bioorthogonal probes in inflammatory macrophages. J.Am. Chem. Soc. 2020, 142 (25), 10894-10898.
2. Qin, W.; Qin, K.; Zhang, Y.;Jia, W.; Chen, Y.; Cheng, B.; Peng, L.; Chen, N.; Liu, Y.; Zhou,W.; Wang, YL.; Chen, X.; Wang, C., S-glycosylation-based cysteine profilingreveals regulation of glycolysis by itaconate. Nat. Chem. Biol. 2019, 15 (10),983-991.
1. Qin, W.; Lv, P.; Fan, X.; Quan,B.; Zhu, Y.; Qin, K.; Chen, Y.; Wang, C.; Chen, X., QuantitativeTime-resolved Chemoproteomics Reveals that Stable O-GlcNAc Regulates Box C/DsnoRNP Biogenesis. Proc. Natl. Acad. Sci. USA 2017, 114 (33),E6749-e6758.
